IndraLab

Statements

USP15 increases the amount of RELA. 5 / 5
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"USP15 silencing induced MM cell proliferation inhibition, apoptosis, and the expression of nuclear and cytoplasmic NF-kappaBp65, while USP15 overexpression exhibited an inverse effect."
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"USP15 promoted NF-kappaBp65 expression through inhibiting ubiquitination."
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"Moreover, in vivo experiments indicated that USP15 silencing inhibited MM tumor growth and NF-kappaBp65 expression."
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"Also, USP15 up-regulation can increase RelA levels by inhibiting its ubiquitination [23,50] ."
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"These results suggest that USP15 promotes NF-kappaBp65 expression through deubiquitination."
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