IndraLab

Statements

BAP1 inhibits Mesothelioma. 6 / 6
| 6
reach
"Loss of BAP1 was shown to increase enhancer of zeste homolog 2 (EZH2) levels in a mesothelioma model , and to increase sensitivity to EZH2 inhibition."
33144689
reach
"We investigated whether loss of BAP1 expression can be used to support a diagnosis of mesothelioma in effusion cytology."
26373699
reach
"BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms."
36550359
reach
"While the potential link between BAP1 loss—a known driver of mesothelioma—with response to ICI treatments is intriguing, an important caveat is that BAP1 resides at 3p21.1, a chromosomal region that also contains two other genes encoding epigenetic regulators, PBRM1 and SETD2."
30914057
reach
"EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study."
35588752
reach
"Germline mutations in BAP1 predispose carriers to the BAP1 tumor predisposition syndrome (BAP1-TPDS), characterized by BAP1-inactivated nevi (BINs), uveal melanoma, cutaneous melanoma, mesothelioma, renal cell carcinoma, and other tumors."
32249949