IndraLab

Statements


TP53 binds MDM2 and TAp73α. 5 / 5
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sparser
"In control experiments we showed that endogenous p53 R175H simultaneously interacted with endogenous TAp73α and MDM2 forming a three-body complex (Figure xref right panel)."

sparser
"This data suggests that the formation of p53 R175H-TAp73α-MDM2 complex could additionally decrease the cellular apoptotic response, thus increasing chemoresistance (Figure xref )."

sparser
"In the case of H1299 lung cancer cells, ectopic expression of MDM2 released HSPA1A/HSP70 and DNAJB1/HSP40 from the p53 R175H-TAp73α complex in a dose dependent manner, thus leading to the formation of p53 R175H-TAp73α-MDM2 complex (Figure xref )."

sparser
"Thus, one could argue that the conformation of the proteins forming the p53 R175H-TAp73α complex is different than the conformation of the components forming the three-body p53 R175H-TAp73α-MDM2 complex."

sparser
"Moreover, the formation of p53 R175H-TAp73α-MDM2 complex was suggested in HCT116 ( TP53 −/− ) cells with ectopic expression of each protein of the complex."