IndraLab

Statements

KCNH2 activates lanosterol. 3 / 3
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"The overexpression of the gene ERG1 (squalene epoxidase) induced a significant decrease of the direct substrate squalene, a high increase of lanosterol, and a small increase of later sterols."
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"Then, the obtained FPP synthesizes lanosterol by farnesyl-diphosphate farnesyltransferase (FDFT1), ERG1, and lanosterol synthase (ERG7)."
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"In the post-squalene pathway, overexpression of ERG1 led to a significant decrease in squalene accumulation, accompanied by a large increase in lanosterol and a slight increase in later sterols from zymosterol to ergosterol, while overexpression of ERG11 reduced the accumulation of lanosterol and increased the amounts of the downstream sterols (Veen et al. 2003)."
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