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USP2 deubiquitinates CRY1. 3 / 3

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"In addition to PER1 and BMAL1, USP2 deubiquitinates CRY1 in cultured cells in response to a serum shock, and in the mouse liver, Usp2 knockdown increases CRY ubiquitination and decreases CRY1 protein levels."

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"USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals."

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"USP2 is essential to deubiquitinating PER1, CRY1 and CRY2 in vivo [54–57]."

32705594

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USP2 deubiquitinates CRY1. 3 / 3

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