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USP2 deubiquitinates CRY1. 3 / 4
1 | 3

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"Further, USP2 is able to deubiquitinate the ubiquitinated forms of the clock proteins BMAL1 (Scoma et al. 2011), PER1 (Yang et al. 2012) and CRY1 (Tong et al. 2012)."

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"In addition to PER1 and BMAL1, USP2 deubiquitinates CRY1 in cultured cells in response to a serum shock, and in the mouse liver, Usp2 knockdown increases CRY ubiquitination and decreases CRY1 protein levels."

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"USP2 is essential to deubiquitinating PER1, CRY1 and CRY2 in vivo [54–57]."