IndraLab

Statements

USP22 activates SIRT1. 3 / 4
| 3
reach
"USP22 also increases SIRT1 protein stability, which leads to the suppression of p53 transcriptional activity and inhibition of cell death [XREF_BIBR, XREF_BIBR]."
27057639
reach
"USP22 mediates stabilization of Sirt1 by interacting and removing poly-ubiquitin chains previously conjugated to Sirt1."
32532965
reach
"Simply put, USP22 may activate the SIRT1–AKT–MRP1 pathway and consequently promote MDR in human HCC cells (226)."
31608282