IndraLab

Statements

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"91 Likewise, as a part of the PKA signaling pathway, cyclic adenosine monophosphate (cAMP) can also directly inhibit the NLRP3 inflammasome at Ser295 of its receptor."
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"Dopamine D receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway negatively regulates NLRP3 inflammasome in both primary microglia and astrocytes."
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"Yan et al (32) demonstrated that the NLRP3 inflammasome is negatively regulated by cyclic adenosine monophosphate–dependent molecule-specific selective autophagy through the activation of MARCH7, an E3 ubiquitin-protein ligase."
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"CD39 expressing DCs converted extracellular ATP to ADP and AMP molecules, which were critical to down-regulate NLRP3 inflammasome and protect the host from experimental autoimmune encephalomyelitis (EAE)."
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"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition."
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"Similarly, a synthetic AMP GW-A2 inhibits inflammatory response and NLRP3 inflammasome by neutralizing LPS and ATP, which provides a foundation for the design of rational therapeutics for inflammation-related diseases (40)."
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"AMP-mediated NLRP3 inflammasome inhibition in THP-1 macrophages increased cell viability and migratory capacity in HaCaT cells."
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"Of note, this previous study indicates that inhibition of AMP activated protein kinase (AMPK) can promote NLRP3 inflammasome activation by LPS and FFAs such as palmitate, but not by NLRP3 inflammasome activators used in our study such as ATP and nigericin 4."
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