IndraLab

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USP35 activates USP30. 1 / 1
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"This may suggest that USP35 plays additional roles in the cytosol to delay PARK2 mediated mitophagy.Overexpressing USP30 but not USP35 delays PARK2 recruitmentIn cells with a healthy mitochondrial network, PARK2 is diffused in the cytosol and not on mitochondria.9 However, following mitophagy activation by CCCP treatment, PARK2 is recruited to mitochondria within 1 h."