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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNFAIP3 activates Dendritic Cells. 2 / 2

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"These observations suggested that the proinflammatory DC phenotype was induced by the caerin gel.Caerin gel treatment significantly upregulated the expression of Tnfaip3 in NK cells."

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"20 , 21 Several models of DC‐specific deletion of TNFAIP3 in CD11c cells have shown that this molecule limits DC activation, and in the absence of TNFAIP3, DCs produce higher levels of cytokines, express higher co‐stimulatory molecules, resist to cell death, and activate auto‐reactive T‐ and B‐cell responses."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...