IndraLab

Statements

USP4 activates IL1B. 3 / 3
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"Knockdown of USP4 promoted IL-1beta, LPS, and TGF-beta-induced NF-kappaB activation (Fan et al., 2011)."
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"Mechanistically, USP4 can directly bind to the TRAF domain to inhibit TRAF2/TRAF6 activity through deubiquitination in an activity-dependent manner and negatively regulate IL-1β and TNF-α-induced NF-κB activation, thereby inhibiting lung cancer metastasis (46)."
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"Notably, USP4 overexpression antagonized OGD/R-induced IL-1β, IL-6, and TNF-α transcriptional levels (Fig. 3A–C)."
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