IndraLab

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Astemizole decreases the amount of KCNH1. 4 / 5
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR In addition, astemizole potentiates the effect of other anticancer drugs in leukemia and breast cancer cells and downregulates Eag1 mRNA expression in breast cancer cells; in addition, astemizole binds to chromatine."
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"Interestingly, the expression of EAG1 was also inhibited by astemizole, in a similar manner as observed previously in vitro [XREF_BIBR]."
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"Previous in vitro studies by our group have shown that astemizole, a non selective EAG1 blocker, synergized with calcitriol to inhibit breast cancer cell proliferation by modifying EAG1 gene expression and possibly its activity as well [XREF_BIBR]."
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"As depicted in XREF_FIG, calcitriol or astemizole alone slightly reduced Eag1 and Ki-67 gene expression in IDC-1; however, when used concomitantly, a significant inhibition of gene expression was observed for both genes."
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