IndraLab

Statements

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"The TGF-beta gene also activates miR-182, which can affect the CYLD gene, which can further contribute to the activation of NF-kappaB, which was demonstrated in the case of glioblastoma, and subsequently lead to angiogenesis and tumor invasion [XREF_BIBR]."
| PMC
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"These findings suggest that downregulation of CYLD promotes invasion with mesenchymal transition via ALK5 stabilization in OSCC cells."
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"Poor CYLD expression enhanced OSCC tumor invasion, suggesting low patient survival rates."
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"Furthermore, CYLD overexpression inhibited SMAD7 mediated cell invasion, while CYLD depletion increased SMAD7 mediated cell invasion in OSCC cells."
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"Studies found that miR-362-5p reduces the expression of tumor suppressor protein CYLD, which leads to activate the NF-kB pathway to promote the proliferation, migration, and invasion of hepatocellular carcinoma cells and human breast cancer cells (Ni et al., 2015; Ni et al., 2016)."
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