IndraLab

Statements

USP13 inhibits PTEN. 8 / 10
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"Down-regulation of USP13 mediates PTEN protein loss and fibroblast phenotypic change, and thereby plays a crucial role in IPF pathogenesis."
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"Zhang et al. reported that USP13 suppresses tumorigenesis and glycolysis in PTEN-positive breast cancer through the deubiquitination of PTEN [18]."
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"USP13 increases PTEN stability [126] , whereas USP7 reverses monoubiquitylation and nuclear accumulation of PTEN [125] ."
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"For example, overexpression of USP13 blocks the AKT signaling pathway and suppresses tumor cell proliferation, invasion, and glycolysis by upregulating PTEN, while USP13 levels are downregulated in breast, bladder, and oral squamous tumors, in correlation with PTEN levels (Fig. 3)."
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"In addition to its role in breast cancer, USP13 has been demonstrated to suppress tumor development via PTEN in oral squamous cell cancer [36] and bladder cancer [19]."
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"Conversely, overexpression of USP13 suppresses tumorigenesis and glycolysis in PTEN positive but not PTEN-null breast cancer cells."
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"The coding sequence of USP13 or PTEN was amplified with the following primers: USP13 (NM_003940.2), forward 5′-CGGAATTCATGCAGCGCCGGG-3′ and reverse 5′-CGGGATCCTTAGCTTGGTATCCTGCGG-3′; and PTEN (CR450306.1), forward 5′-CGGAATTCATGACAGCCATCATCAAAGAG-3′ and reverse 5′-CGGGATCCCGATCTCTTTGATGATGGCTG-3′."
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"Previous research showed that depletion of USP13 in breast cancer led to increased Akt phosphorylation, cell proliferation on 2D and 3D, glycolysis, and tumor growth by downregulating PTEN tumor suppressor proteins (25)."
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