IndraLab

Statements

Hemin inhibits EIF2AK1. 6 / 6
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"The results are as follows : (i) Both hemin and p67 inhibited HRI (heme regulated protein synthesis inhibitor) and dsI (double stranded RNA activated protein synthesis inhibitor) catalyzed phosphorylation of eIF-2 alpha-subunit in vitro."
7911326
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"It was interesting to observe that hemin downregulated HRI promoter activity in a dose dependent manner."
16500424
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"Most recently, Hsp70 has been shown to prevent the activation of HRI in hems deficiency by reducing the optimal concentration of hemin required to suppress HRI activatian2s."
7709427
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"We conclude that disulfide formation by hemin provides a likely mechanism by which hemin prevents the activation and inhibits the activity of HRI."
2722851
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"Contrary to this, hemin, a suppressor of HRI kinase activity, downregulated HRI promoter activity and stimulated hemoglobin synthesis."
16500424
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"Delayed addition of hemin to shut-off lysates inhibits the eIF-2alpha kinase activity of HRI and restores protein synthesis; under those conditions, the endogenous phosphatase of the lysate dephosphorylates phosphorylated eIF-2alpha and restores eIF-2B activity."
8619603