IndraLab

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Hemin inhibits EIF2AK1. 6 / 6
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"Delayed addition of hemin to shut-off lysates inhibits the eIF-2alpha kinase activity of HRI and restores protein synthesis; under those conditions, the endogenous phosphatase of the lysate dephosphorylates phosphorylated eIF-2alpha and restores eIF-2B activity."
8619603
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"It was interesting to observe that hemin downregulated HRI promoter activity in a dose dependent manner."
16500424
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"Heme regulated inhibitor (HRI) is activated by hemin deprivation, double stranded RNAdependent kinase (PKR) is activated by double stranded RNA, PKR like endoplasmic reticulum kinase (PERK) is activated by unfolded proteins and ischemia and reperfusion, and the general amino acid control eIF2 protein kinase (GCN2) is activated by serum or amino acid starvation (Kumar et al., 2001)."
15005178
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"The results are as follows : (i) Both hemin and p67 inhibited HRI (heme regulated protein synthesis inhibitor) and dsI (double stranded RNA activated protein synthesis inhibitor) catalyzed phosphorylation of eIF-2 alpha-subunit in vitro."
7911326
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"Most recently, Hsp70 has been shown to prevent the activation of HRI in hems deficiency by reducing the optimal concentration of hemin required to suppress HRI activatian2s."
7709427
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"We conclude that disulfide formation by hemin provides a likely mechanism by which hemin prevents the activation and inhibits the activity of HRI."
2722851