IndraLab

Statements

USP19 activates TGFB. 3 / 3
| 3
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"Here, we demonstrated that USP19-CY promotes TGF-beta signaling by directly interacting with TGF-beta type I receptor (TbetaRI) and protecting it from degradation at the plasma membrane."
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"Taken together, these results suggest that the catalytic activity of USP19-CY is required to promote TGF-β signaling, while USP19-ER inhibits TGF-β signaling in a DUB activity-independent manner."
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"USP19-CY promotes TGF-beta signaling, while USP19-ER exerts the opposite effect."
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