IndraLab

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BAP1 increases the amount of SLC7A11. 18 / 18
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"Conversely, BAP1 deficiency by CRISPR technology increased SLC7A11 expression in several BAP1-proficient renal cancer cells with low SLC7A11 levels, including 786-O, Caki1, and ACHN cells (XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
30202049
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"The tumor suppressor protein BRCA1-associated protein 1 (BAP1) inhibits SLC7A11 expression in a deubiquitinating-dependent manner and induces lipid peroxidation to promote ferroptosis (53)."
36185243
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"As discussed in Boxes 2 and 3, inactivation of tumour suppressors such as p53, BAP1, kelch-like ECH associated protein 1 (KEAP1) and ARF (p14), or activation of oncogenic KRAS, upregulates SLC7A11 expression, which can be dependent or independent of nuclear factor erythroid 2-related factor 2 (NRF2), conferring ferroptosis evasion and promoting tumour growth ."
35338310
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"Another tumor suppressor, BAP1, which is often lost or mutated in various cancers, has been shown to inhibit SLC7A11 expression, thereby reducing cystine uptake and facilitating ferroptosis in cancer cells."
40123584
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"BAP1 interacts with Nrf2 to modulate SLC7A11 expression and GSH levels [116,117,118]."
| PMC
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"Moreover, tumor suppressor factor BAP1, an epigenetic regulator, has also been shown to downregulate SLC7A11 expression to promote ferroptosis, but the extent of BAP1’s pro-ferroptotic activity in tumor suppression remains unclear (Zhang et al., 2018)."
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"For example, the tumor suppressor gene, BRCA1-associated protein 1 (BAP1), promotes lipid peroxidation by downregulating the expression level of SLC7A11, thereby promoting tumor cell ferroptosis (42)."
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"This is consistent with our finding that BAP1 represses SLC7A11 expression (therefore, lower dosages of erastin were needed to block SLC7A11 activity and to induce ferroptosis in BAP1 expressing cells, which exhibited lower expression of SLC7A11)."
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"The tumor suppressor BRCA1 associated protein 1 (BAP1) represses SLC7A11 expression via reducing H2Aub occupancy on SLC7A11 promoter in a deubiquitinating dependent manner [XREF_BIBR]."
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"BAP1 mediated deubiquitination of histone 2A ubiquitination (H2Aub), while monoubiquitination of histone H2B on lysine 120 (H2Bub1) induced the expression of SLC7A11 during ferroptosis and consequentl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38246223
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"The tumor suppressor BRCA1-associated protein 1 inhibits the growth of cancer cells by regulating the expression of SLC7A11 (Zhang et al., 2019), and its effect is similar to Erastin."
34869391
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"Similarly, another group reported that tumor suppressor BRCA1-associated protein 1 (BAP1) protein repressed the expression of SLC7A11 in a deubiquitinating-dependent manner, resulting in accumulation of lipid peroxidation and ferroptosis."
36851083
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"BAP1 removes H2A ubiquitination on the SLC7A11 promoter and reduces SLC7A11 transcription through its deubiquitinating activity, thereby curbing cystine uptake and promoting ferroptosis."
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"In normal cells, BAP1 promotes ferroptosis by inhibiting SLC7A11 gene expression and cysteine uptake."
37658030
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"The mechanism may be that BAP1 suppresses SLC7A11 transcription by reducing histone 2A ubiquitination (H2Aub) on the SLC7A11 gene."
37299036
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"The tumor suppressor BAP1, an H2A deubiquitinating enzyme, can reduce SLC7A11 expression by inhibiting H2A ubiquitination (H2Aub) on the SLC7A11 promoter, thus controlling ferroptosis (Zhang Y.L."
34568341
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"As a particular SMG of C1, BAP1 has been certified to block cystine uptake by inhibiting the expression of SLC7A11, leading to lipid peroxidation and ferroptosis, thereby inhibiting tumor progression."
33738257
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"BRCA1-associated protein 1 (BAP1) could promote ferroptosis by blocking the expression of SLC7A11."
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