IndraLab

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BAP1 increases the amount of SLC7A11. 8 / 8
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"The tumor suppressor BRCA1 associated protein 1 (BAP1) represses SLC7A11 expression via reducing H2Aub occupancy on SLC7A11 promoter in a deubiquitinating dependent manner [XREF_BIBR]."
33425217
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"As a particular SMG of C1, BAP1 has been certified to block cystine uptake by inhibiting the expression of SLC7A11, leading to lipid peroxidation and ferroptosis, thereby inhibiting tumor progression."
33738257
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"As discussed in Boxes 2 and 3, inactivation of tumour suppressors such as p53, BAP1, kelch-like ECH associated protein 1 (KEAP1) and ARF (p14), or activation of oncogenic KRAS, upregulates SLC7A11 expression, which can be dependent or independent of nuclear factor erythroid 2-related factor 2 (NRF2), conferring ferroptosis evasion and promoting tumour growth ."
35338310
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"Functional studies reveal that BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitinating dependent manner, and that BAP1 inhibits cystine uptake by repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis."
30202049
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"The tumor suppressor BRCA1-associated protein 1 inhibits the growth of cancer cells by regulating the expression of SLC7A11 (Zhang et al., 2019), and its effect is similar to Erastin."
34869391
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"The tumor suppressor BAP1, an H2A deubiquitinating enzyme, can reduce SLC7A11 expression by inhibiting H2A ubiquitination (H2Aub) on the SLC7A11 promoter, thus controlling ferroptosis (Zhang Y.L."
34568341
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"Conversely, BAP1 deficiency by CRISPR technology increased SLC7A11 expression in several BAP1-proficient renal cancer cells with low SLC7A11 levels, including 786-O, Caki1, and ACHN cells (XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
30202049
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"The tumor suppressor protein BRCA1-associated protein 1 (BAP1) inhibits SLC7A11 expression in a deubiquitinating-dependent manner and induces lipid peroxidation to promote ferroptosis (53)."
36185243