IndraLab

Statements

ESR1 binds KCNH2. 2 / 2
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"The group recently demonstrated that 1) once-hypoxic females are protected from methylation of the promoter sites by estrogen receptor interactions with the ERG-1 promoter site [ xref ] and 2) in a different set of experiments, norepinephrine treatment of adult male rats caused hypertrophy and the associated hypermethylation could be reversed with 5-aza-2′-deoxycytidine treatment over the last 6 days of norepinephrine infusion."
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"Moreover, hERG1 scoring was significantly associated with ER expression, with higher hERG1 scoring in ER-positive samples (p = 0.008), and inversely associated with Ki67 (higher hERG1 scoring in samples with Ki67 index lower to 15%, p = 0.038)."
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