IndraLab

Statements

USP46 increases the amount of phosphorylated ERK. 2 / 2
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"As shown in Fig. 7j and Supplementary Fig. 10g, the overexpression of USP46 WT, but not the 3 A mutant in SK-MEL-103, SK-MEL-30 and SK-MEL-2 cells significantly increased the protein level of NRAS mutants and levels of p-AKT and p-ERK."
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"Furthermore, the depletion of USP46 in SK-MEL-103, SK-MEL-30 and SK-MEL-2 cells significantly suppressed levels of p-AKT and p-ERK, cellular proliferation, migration and invasion abilities along with increased cellular sensitivity to DTIC, whereas the reconstitution of NRAS Q61R/K, NRAS Q61R-K135R + K147R or NRAS Q61R-K135R + K147L in USP46-deficient cells markedly rescue such effects (Fig. 5i–l and Supplementary Figs."
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