IndraLab

Statements

UCHL1 activates APP. 3 / 6
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reach
"34 UCHL1 is also required for normal synaptic function and rescues Abeta related synaptic dysfunction in transgenic AD mice."
21368863
eidos
"UCH-L1 ameliorates Abeta ( 1-42 ) - induced LTP loss in vitro and in vivo ."
30216447
reach
"BACE1 has been reported to be degraded by the lysosomes and ubiquitin-proteasome pathway, and accelerating BACE1 degradation by ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) reduces 99-amino acid carboxy-terminal fragment (C99) and Abeta production."
27047374