IndraLab

Statements

UCHL1 activates APP. 5 / 8
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reach
"The circular RNA circular RNA sponge for miR-7 (ciRS-7) inhibits the expression of UCHL1 to promote APP and BACE1 degradation by inhibiting the translation of NF-κB and inducing its cytoplasmic localization (Shi et al., 2017)."
39281280
reach
"It will be very important to determine whether UCH-L1 acts to reverse a single deleterious effect of oligomeric Aβ, or whether it could instead act in a more global way, by destroying or “neutralizing[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16923386
eidos
"UCH-L1 ameliorates Abeta ( 1-42 ) - induced LTP loss in vitro and in vivo ."
30216447
reach
"BACE1 has been reported to be degraded by the lysosomes and ubiquitin-proteasome pathway, and accelerating BACE1 degradation by ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) reduces 99-amino acid carboxy-terminal fragment (C99) and Abeta production."
27047374
reach
"34 UCHL1 is also required for normal synaptic function and rescues Abeta related synaptic dysfunction in transgenic AD mice."
21368863