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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 activates APP. 3 / 6

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"34 UCHL1 is also required for normal synaptic function and rescues Abeta related synaptic dysfunction in transgenic AD mice."

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"UCH-L1 ameliorates Abeta ( 1-42 ) - induced LTP loss in vitro and in vivo ."

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"BACE1 has been reported to be degraded by the lysosomes and ubiquitin-proteasome pathway, and accelerating BACE1 degradation by ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) reduces 99-amino acid carboxy-terminal fragment (C99) and Abeta production."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...