IndraLab

Statements

Modified CTNNB1 phosphorylates CTNNB1. 4 / 4
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reach
"The levels of cytoplasmic beta-catenin are normally controlled by a multi-proteins destruction complex to promote phosphorylation of beta-catenin, which is required to trigger ubiquitination of beta-catenin and its subsequent degradation by proteasomes."
24015932
reach
"These natural products have been found to inhibit the beta-catenin signaling through different molecular mechanisms (XREF_FIG), including, but not limited to, 1) down-regulating beta-catenin expression, 2) modulating beta-catenin phosphorylation, 3) promoting beta-catenin protein degradation, 4) inhibiting beta-catenin nuclear translocation, and others."
32695004
reach
"In addition, AXIN2 is induced in response to increased beta-catenin levels and promotes phosphorylation of beta-catenin by Glycogen synthase kinase 3 (GSK3), thereby targeting it to degradation."
30046100
reach
"Several natural products have been shown to inhibit the beta-catenin signaling via different molecular mechanisms, including, but not limited to, 1) down-regulating beta-catenin expression, 2) modulating beta-catenin phosphorylation and inducing its inactivation, 3) promoting beta-catenin protein ubiquitination and proteasomal degradation, 4) inhibiting beta-catenin nuclear translocation, and 5) other."
32695004