IndraLab

Statements

Mitoxantrone inhibits USP15. 8 / 8
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sparser
"We determined that USP15 is weakly inhibited by mitoxantrone with an IC 50 value of 33 ± 11 μ m ( xref A and)."
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reach
"XREF_BIBR - XREF_BIBR Recently, an anticancer chemotherapy drug, mitoxantrone, has been shown to inhibit USP15, but the potency of USP15 inhibition by this compound is low, and in vivo studies have not been performed."
33436547
reach
"Moreover, we report that USP15 is weakly inhibited by the antineoplastic agent mitoxantrone in vitro A USP15 and mitoxantrone complex structure disclosed that the anthracenedione interacts with the S1 ' binding site."
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eidos
"In addition , it was found that mitoxantrone weakly inhibits the activity of USP15 with an IC50 of 33 muM ."
33925279
sparser
"Moreover, we report that USP15 is weakly inhibited by the antineoplastic agent mitoxantrone in vitro ."
30228188
sparser
"Furthermore, we show that mitoxantrone weakly inhibits USP15 and determined a mitoxantrone–USP15 complex structure."
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sparser
"Crystal structure analysis by Ward et al. highlighted minute differences between the paralogs and noted that mitoxantrone binds and partially inhibits USP15, similar to USP11."
31481479
sparser
"We subsequently tested whether USP15 is inhibited by mitoxantrone using a diubiquitin gel shift cleavage assay, as this agent has previously been shown to inhibit the homolog USP11 ( xref )."
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