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OTUD6A binds CDC6. 8 / 8
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"We showed that DNA damage promotes the binding of OTUD6A to CDC6, subsequently upregulating CDC6 protein level, activating the ATR-Chk1 pathway and resulting in chemoresistance (Fig. 8)."
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"Tissue specimens were used to determine the association between OTUD6A and CDC6."
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"OTUD6A interacts with, depolyubiquitinates and stabilizes CDC6 by removing K6-, K33-, and K48-linked polyubiquitination."
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"Importantly, the interaction between OTUD6A and CDC6 was detected in late S phase and occurred predominantly in G2/M phase, following the same trend as CDC6 protein level (Fig. 2h, i)."
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"HU treatment, which increased CDC6 expression, effectively promoted the interaction between OTUD6A and CDC6, indicating that replication stress enhanced the binding capacity between OTUD6A and CDC6 (Fig. 2j)."
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"However, the interaction between CDC6 and OTUD6A was not changed in cells treated with the CDK2 inhibitor CVT-313 compared with that in control cells (Supplementary Fig. 2j)."
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"Although mutation of OTUD6A did not affect the interaction between OTUD6A and CDC6 (Supplementary Fig. 3h), the C152A mutant of OTUD6A lost the ability to upregulate CDC6 (Fig. 3h, i and Supplementary Fig. 3i-m)."
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"We further investigated the role of interaction between CDC6 and OTUD6A in CDC6 protein regulation."
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