IndraLab

Statements

TNF activates OTULIN. 11 / 11
| 11
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"Significantly, the fact that the here described OTULIN related autoinflammatory syndrome and ORAS can be treated with TNF neutralizing antibodies suggests a potential therapeutic strategy to treat conditions caused by excessive M1 linked polyUb signaling."
27523608
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"XREF_FIG E, cholera toxin strongly inhibited SNX27 mediated TNFalpha stimulation mediated OTULIN membrane localization."
| PMC
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"TNF induces IEC apoptosis and lethality in OTULIN IEC-KO mice."
37598207
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"The deubiquitinase OTULIN removes methionine 1 (M1)-linked polyubiquitin signals conjugated by the linear ubiquitin chain assembly complex (LUBAC) and is critical for preventing TNF driven inflammation in OTULIN related autoinflammatory syndrome (ORAS)."
30804083
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"However, given the importance of upstream TNF signaling in OTULIN-related pathogenesis, it is not surprising that most patients show positive clinical responses to TNF inhibition (Figure 3D)."
38712244
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"We present here an integrated set of demonstrated or potentially inflammation-repressive proteins or protein complexes (linear ubiquitin chain assembly complex [LUBAC], cylindromatosis lysine 63 deubiquitinase [CYLD], tumor necrosis factor alpha-induced protein 3-interacting protein 1 [TNIP1], A20, and OTULIN) for a comprehensive view of cytoplasmic signaling highlighting protein players repressing inflammation as the needed counterpoints to signal activators and amplifiers."
37569318
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"Importantly, similar effects were obtained when the OTULIN deficient patients were treated with the TNF antagonist infliximab."
28408979
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"Whereas ORAS patients display enhanced myeloid-driven inflammation, type I IFN responses, and increased susceptibility to TNF-driven cell death (5, 6, 9, 11), OTULIN haploinsufficient patients [including 5p− syndrome (Cri Du Chat) patients representing a phenocopy of OTULIN haploinsufficiency] have no overt immunological abnormalities but do have an increased susceptibility to cytotoxic effects of the S. aureus alpha toxin based on increased OTULIN-dependent caveolin 1 accumulation in dermal fibroblasts (1)."
38827742
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"However, whether this is due to changes in E3 ligase activity (cIAP and LUBAC) or deubiquitinating enzymes (CYLD, tumor necrosis factor alpha-induced protein 3 (Tnfip3 or A20), and OTU deubiquitinase with linear linkage specificity (OTULIN)) is unclear."
32764479
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"However, although A20 and CYLD are induced by TNFalpha for the establishment of a negative feedback loop, neither OTULIN (XREF_FIG F) nor LUBAC are induced by TNFalpha, again suggesting that they function as a differentially regulated signaling module."
23746843
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"XREF_FIG A, the interaction between endogenous SNX27 and OTULIN was upregulated when cells were treated with TNFalpha for 5min."
| PMC