IndraLab

Statements

TNF activates OTULIN. 7 / 7
| 7
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"Importantly, similar effects were obtained when the OTULIN deficient patients were treated with the TNF antagonist infliximab."
28408979
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"XREF_FIG E, cholera toxin strongly inhibited SNX27 mediated TNFalpha stimulation mediated OTULIN membrane localization."
| PMC
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"XREF_FIG A, the interaction between endogenous SNX27 and OTULIN was upregulated when cells were treated with TNFalpha for 5min."
| PMC
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"However, whether this is due to changes in E3 ligase activity (cIAP and LUBAC) or deubiquitinating enzymes (CYLD, tumor necrosis factor alpha-induced protein 3 (Tnfip3 or A20), and OTU deubiquitinase with linear linkage specificity (OTULIN)) is unclear."
32764479
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"However, although A20 and CYLD are induced by TNFalpha for the establishment of a negative feedback loop, neither OTULIN (XREF_FIG F) nor LUBAC are induced by TNFalpha, again suggesting that they function as a differentially regulated signaling module."
23746843
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"Significantly, the fact that the here described OTULIN related autoinflammatory syndrome and ORAS can be treated with TNF neutralizing antibodies suggests a potential therapeutic strategy to treat conditions caused by excessive M1 linked polyUb signaling."
27523608
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"The deubiquitinase OTULIN removes methionine 1 (M1)-linked polyubiquitin signals conjugated by the linear ubiquitin chain assembly complex (LUBAC) and is critical for preventing TNF driven inflammation in OTULIN related autoinflammatory syndrome (ORAS)."
30804083