IndraLab

Statements

USP8 binds ITCH. 4 / 4
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"Altogether, these results demonstrated that 9F7-F11 induced USP8 recruitment to stabilize ITCH, and then, the USP8-ITCH complex binds to the ITCH targets c-FLIP L and HER3, allowing their ubiquitination and proteasomal degradation."
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"One such example has been described for the Itch-Usp8 ‘partnership’, where Usp8 increases the activity of Itch by deubiquitination [ xref ]."
35044632
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"For the interaction of Usp8 and Itch, it has been described that the deubiquitinase Usp8 removes ubiquitin chains on the E3-ligase Itch, which increases its activity towards cFLIP S [ xref ]."
35044632
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"USP8 deubiquitinates and stabilizes ITCH, and forms a USP8-ITCH complex, which then mediates the ubiquitination and subsequent proteasomal degradation of cellular FLICE - like inhibitory protein (c-FLIP), ultimately promoting caspase-8-mediated apoptosis in cancer cells [ xref ]."
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