IndraLab

Statements

LUM activates KCNH2. 3 / 3
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reach
"[XREF_BIBR] The mechanisms by which LUM may rescue hERG trafficking defects are still unknown and these results will require extensive confirmation from clinical data and from other hiPSC lines from more LQT2 donors to verify whether these effects could be cell-line- or mutation specific or whether their mechanism could be exploited for broader applications."
31114684
reach
"While LUM treatment failed to rescue the hERG trafficking defect in TSA201 cells, LUM rescued channel trafficking for all mutations in the iPSC-CM model."
32940533
reach
"We hypothesize that LUM might rescue also hERG trafficking defects in LQT2 and exert anti-arrhythmic effects."
29020304