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USP28 deubiquitinates FOXM1 on M1. 2 / 2
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"In another study, a reduction in G0/G1-phase cells and an increase in S-phase cells were observed in pancreatic cancer cells with ectopic expression of USP28, and this advancement in cell proliferation was mediated by the deubiquitination of Forkhead box M1 (FOXM1), which is induced by USP28 [4]."
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"USP28 deubiquitinates and stabilizes the forkhead box M1 (FOXM1) transcription factor, which, in turn, activates the Wnt/β-catenin pathway and subsequently the expression of many EMT-related genes [146,195]."
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