IndraLab

Statements

reach
"The decrease was not observed when IkappaBalpha resynthesis was inhibited by cycloheximide."
10340762
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"We measured expression of endogenous IkappaBalpha in C2C12 cells by inducing with TNF-alpha or taxol in medium to which 100 microg/ml cycloheximide (CHX) had been added in order to prevent synthesis of new IkappaBalpha (XREF_FIG)."
19732770
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"Consistent with endogenous activation of NF-kappaB signaling by taxol we showed that, similar to TNF-alpha, taxol treatment in the presence of cycloheximide significantly reduced IkappaBalpha suggesting that both molecules induce proteasomal degradation of IkappaBalpha."
19732770
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"We examined the possibility of Casp12 on the post-translational degradation of IkappaBalpha, NPC cells were treated with cycloheximide (CHX) in the presence and absence of Z-ATAD-fmk for the indicated time."
28380444
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"The 60-min nadir is due to a rapid IkappaBalpha resynthesis that reassociates with Rel A and completely inhibits its DNA binding activity; the 60-min nadir is not observed when IkappaBalpha resynthesis is prevented by cycloheximide treatment."
9092517
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"In addition, cycloheximide suppressed IkappaBalpha resynthesis and prolonged p38MAP kinase activation and these changes were associated with sustained activation of the transcription factor NF-kappaB."
15034930
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"We found that SCF in presence of cycloheximide, a protein-biosynthesis inhibitor, induces IkappaBalpha degradation (data not shown)."
26353931