IndraLab

Statements

USP22 ubiquitinates FBP1. 4 / 4
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"Ablation of USP22 does not affect the protein stability of FBP1 but increases ubiquitination of FBP1 and decreases FBP1 occupancy at the p21 gene [13] ."
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"Recent studies have demonstrated that USP22 can inhibit the transcription of the p21 gene by de-ubiquitinating the transcriptional regulator FBP1, leading to cell proliferation and tumorigenesis [XREF_BIBR]."
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"A previous study demonstrated that USP22 could inhibit the transcription of the cyclin-dependent kinase inhibitor 1A (p21) gene by deubiquitinating the transcriptional regulator fructose-1,6-bisphosphatase (FBP1) (5)."
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"USP22 also suppresses CDKN1A and p21 -locus expression by deubiquitinating its transcriptional repressor FBP1 (Atanassov and Dent, 2011), and acts as a negative regulator of the tumor suppressor p53 b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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