IndraLab

Statements

ATXN3 activates transport. 2 / 2
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reach
"Recent evidence indicates that aggresome formation is mediated by dynein and dynactin mediated microtubule based transport of misfolded proteins to the centrosome and involves several regulators, including histone deacetylase 6, E3 ubiquitin protein ligase parkin, deubiquitinating enzyme ataxin-3, and ubiquilin-1."
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reach
"Previous reports showed that ATXN3 interacts with tubulin and microtubules (Rodrigues et al., 2010) and also with HDAC6 and dynein to promote aggresome transport to the microtubule organization center (MTOC) (Burnett and Pittman, 2005)."
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