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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 activates transport. 2 / 2

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"Recent evidence indicates that aggresome formation is mediated by dynein and dynactin mediated microtubule based transport of misfolded proteins to the centrosome and involves several regulators, including histone deacetylase 6, E3 ubiquitin protein ligase parkin, deubiquitinating enzyme ataxin-3, and ubiquilin-1."

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"Previous reports showed that ATXN3 interacts with tubulin and microtubules (Rodrigues et al., 2010) and also with HDAC6 and dynein to promote aggresome transport to the microtubule organization center (MTOC) (Burnett and Pittman, 2005)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...