IndraLab

Statements

USP22 activates USP22. 5 / 5
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"In addition, phosphorylation of Thr147 and Ser237 of USP22 by CDK1 enhances the deubiquitination activity of USP22 on cyclin B1."
33989708
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"Phosphorylation of USP22 at T147 and S237 by cyclin dependent kinase 1 (CDK1) was shown to activate USP22 to deubiquitylate cyclin B1."
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"Unsurprisingly, the expression level of USP22 protein in HG-induced INS-1 cells was dramatically increased after transfecting USP22 OE."
35761309
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"Interestingly, USP22 activity is regulated by CDK1, which catalyzes USP22 phosphorylation to elevate USP22 ability in CCNB1 deubiquitination and stabilization."
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"These findings suggested that activation of the mTORC1 pathway after USP22 overexpression induces therapeutic susceptibility to rapamycin.2.4 USP22 regulates FKBP12 to activate mTORC1 through deubiquitylation."
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