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Neoplasms inhibits BAP1. 8 / 8
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"Subsequent experiments by Ventii et al. (2008) suggested tumor growth suppression of BAP1-restored lung cancers in animal models."
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"Xenografted Ren-02 BAP1 knockdown tumors were excised from mice treated with vehicle (40% PEG-400, 0.9% NaCl, 10% DMSO, filtered) or diABZI (3 mg/kg) twice weekly for 3.5‒5 weeks via intraperitoneal injection."
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"The sPD-L1 level in PE of MPM was lower in BAP1 loss tumors (208.0 ± 167.4 pg/ml) than in BAP1-retained tumors (338.7 ± 457.4 pg/ml, p = 0.085), although the difference was not significant (Supplementary Fig. S4a)."
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"TGF-β in PE of MPM was significantly lower in cases with BAP1 loss tumors (9218 ± 6776 pg/ml) than in cases with BAP1-retained tumors (15,474 ± 15,944 pg/ml, p = 0.023)."
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"However, a limitation of our study is that eye pigmentation is deduced from genotypes, which are also risk SNPs for UM, making it challenging to derive causal statements.Status of chromosome 3 and BAP1 delineates 2 UM subtypes, M3 and BAP1-inactivated high-risk tumors and D3 and wild-type BAP1 low-risk tumors (2-4,8)."
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"Besides, several other transcription factors or tumor suppressors, such as activating transcription factor 3 (ATF3), BRCA1 associated protein-1 (BAP1), ADP-ribosylation factor (ARF), and Kelch-like ECH-associated protein 1 (KEAP1), diminish the expression or suppress the activity of SLC7A11 to induce ferroptosis in cancer cells (Fan et al. 2017; Roh et al. 2017; Wang et al. 2020; Zhang et al. 2018b)."
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"The compound iBAP (36) inhibited truncated-ASXL1-driven leukemic gene expression and hindered tumor progression in vivo , which led to small-molecular catalytic inhibitors of BAP1 as a potential anti-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, fibrotic tumors with histological features of both HCC and FLC have been observed in patients with mutations inactivating BAP1, with a chromosomal gain of PRKACA or loss of PRKAR2A (another inhibitory regulatory subunit) ."
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