IndraLab

Statements

Leupeptin inhibits CTSL. 8 / 8
1 | 7
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"These results suggest that leupeptin treatment caused significant inhibition of the intracellular maturation of cathepsin L."
7581248
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"HIV-luc(ACE2) and HIV(SARS-CoV S/ASLV-A env) particles were mixed, pre-incubated at 37 o C and then treated with PBS, trypsin (10 µg/ml), or cathepsin L or B (2 µg/ml) for 10 minutes at 25 o C. Proteases were inactivated by leupeptin (20 µg/ml), incubated at 37 o C for 30 minutes to allow membrane fusion and plated on HeLa/Tva cells pretreated with leupeptin (20 µg/ml)."
17037535
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"Injection of leupeptin or E-64 into rats actually inhibits the activities of cathepsin B and cathepsin L in the lysosomal fraction of liver and results in inhibition of turnover rate of liver aldolase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7051771
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"Leupeptin and E-64 dose dependently inhibited both cathepsin B and cathepsin L activities, and pepstatin A strongly inhibited cathepsin D activity in rat kidney lysosomes."
10334387
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No evidence text available
9784105
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"Injection of leupeptin into rats [1] actually inhibits the activities of cathepsin B and cathepsin L in the lysosomal fraction of the liver cells."
7020765
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"Previously [1] we found that administration of leupeptin or E-64 to rats inhibited the lysosomal cathepsin B and cathepsin L activity in their liver."
7020765
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"SARS-CoV infection was blocked by specific inhibitors of the pH-sensitive endosomal protease cathepsin L. S-mediated entry into Vero E6 and 293T/hACE2 cells was blocked by leupeptin, Z-lll-FMK (an inhibitor of both CTSB and CTSL), and E64c (an inhibitor of cysteine proteases) [21]."
34239932