IndraLab

Statements

reach
"SP600125 inhibited AP-1 and c-Jun."
21046201
reach
"To further study the functions of transcription factors under hypoxic conditions, JSH-23 and SP600125 were used to block the NF-kappaB and AP-1 and c-Jun pathways."
24002703
reach
"In previously published experiments, 10 muM SP600125 effectively inhibits 90 to 100% of Jun N-terminal kinase activity (Bennett et al., 2001)."
16716376
reach
"Administration of the JNK inhibitor SP600125 or MLK3 (an upstream kinase of MKK7 or MKK4) inhibitor CEP11004 greatly abrogated c-Jun and proliferation, suggesting that the MLK3-MKK4 or 7-JNK cascade contributes to c-Jun activation and cell viability and proliferation."
26734995
reach
"Immunoprecipitation assay showed that hyperosmolarity increased the association of nuclear Sp1 with c-Jun, which was inhibited by U0126 and SP600125."
23816505
reach
"Thrombin (0.3-3.0 U/mL) increased activator protein-1 (AP-1)-luciferase activity, which was inhibited by the JNK inhibitor SP600125."
22212430
reach
"We have determined that SP600125 blocked c-Jun activation in B leukemia cell lines."
21702955
reach
"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580 (Fig. 6a)."
26988982
reach
"In addition, mature oocytes only present a moderate increase of Jun kinase activity, which is not inhibited by SP600125."
27297883
reach
"To clarify the signaling pathways underlying the BDNF expression changes due to Kir4.1 knockdown, astrocytes were pretreated with U0126 [a non competitive inhibitor of mitogen activated protein kinase (MEK) 1/2, 10 muM], SB202190 (an inhibitor of p38 MAPK, 10 muM), or SP600125 [an inhibitor of Jun amino-terminal kinase (JNK), 10 muM] for 30 min before the transfection with Kir4.1 siRNA or a negative control."
29358904
sparser
"TGFβ also induced phosphorylation of (S351) NR4A1, JNK1, c-jun and c-fos which was also inhibited by SP600125, demonstrating that TGFβ induces JNK and genes downstream from JNK."
30072581
reach
"SP600125 has been shown to inhibit Jun N-terminal kinases (JNKs) and other kinases."
24901709
reach
"SP600125, a specific inhibitor of JNK signaling, inhibits the MPTP activated JNK and c-Jun pathway in DA neurons and suppresses cox-2, thereby protecting DA neurons."
33897417
reach
"Further, the inhibitors SB202190 (Sigma-Aldrich) and SP600125 (Sigma-Aldrich) were used to block p38 mitogen activated protein kinase (p38-MAPK) and Jun N-terminal kinase (JNK) respectively in control and siPrdx2 transfected HTR8 cells."
28661480
reach
"The application of JNK inhibitor, SP600125, blocked this increase in phospho-c-Jun, as well as c-Jun activity produced by mustard oil stimulation."
18822271
reach
"SP600125 and TAM67 specifically inhibited JNK and c-Jun signaling as neither agent altered ERK1/2 phosphorylation (XREF_FIG)."
22644775
reach
"Interestingly, the addition of LY294002, SP600125 and PD98059 prevented the fibroin stimulation of c-Jun (XREF_FIG)."
22860103
reach
"Furthermore, MEKK2 immunoprecipitates activated c-Jun in an IL-1 dependent manner and this activity was inhibited by the selective JNK inhibitor SP600125."
14734742
reach
"Notably, to investigate whether the JNK and c-jun pathway participated in mediating the protective functions of 14,15-EET in OGD induced injury of CSMC, SP600125 was used to block the JNK and c-jun pathway."
29081082
reach
"SP600125 inhibited interleukin-1beta-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular regulated kinase, p38 mitogen activated protein kinase, and nuclear factor-kappaB."
15056726
sparser
"In contrast, inhibition of c-Jun NH(2)-terminal kinase (JNK) by SP600125 significantly enhanced apoptosis."
18392682
reach
"As shown in XREF_FIG, SP600125 prevented the cerebral ischemia activation of JNK and c-Jun, an effect that was correlated with a significant attenuation of the induction of Dkk1."
18716201
reach
"To test this possibility, the CXCL14 overexpressing cells (clone H) were incubated with the c-Jun-NH 2 -kinase (JNK) inhibitor SP600125 to block c-Jun (a component of AP-1) activation and then tested if this would cause a decrease of CXCL14 transcription."
19276362
reach
"This rescue depended on PDGF mediated JNK signaling because SP600125 treatment abolished the induction of c-Jun expression (XREF_FIG B)."
20499359
sparser
"In this study, we also showed that SP600125 dramatically inhibited Cd-activated c-Jun, a substrate of JNK in the cells ( xref )."
28129433
reach
"To investigate whether the JNK and c-jun and mTOR pathways were involved in mediating the protective functions of 14,15-EET during OGD induced injury, RAPA and SP600125 were used to block the mTOR and JNK and c-jun pathways, respectively."
29081082
sparser
"Furthermore, inhibition of c-Jun N -terminal kinase (JNK) by SP600125 led to a dramatic decrease of the GLP-induced apoptosis."
24857920
reach
"In this study, we also showed that SP600125 dramatically inhibited Cd activated c-Jun, a substrate of JNK in the cells (XREF_FIG)."
28129433
reach
"Although the SP600125 inhibitor efficiently suppresses activation of c-Jun and the upregulation of ATF-3 in sensory neurons [XREF_BIBR], it did not inhibit neither c-Jun activation nor ATF-3 upregulation in SCs."
24877090
sparser
"Moreover, siG6PD increased the reporter activity of MGAT3 promoters, while inhibition of c-Jun by SP600125 decreased the reporter activity (Fig.  xref , Supplementary Fig.  xref )."
32719549
reach
"In the present study, we demonstrate that an anthrapyrazole SP600125, a reversible ATP-competitive inhibitor of JNK inhibits proliferation of human HMC-1 showed constitutive activation of JNK and c-Jun, and the inhibitory effect of SP600125 on cell proliferation was associated with cell cycle arrest at the G1 phase and apoptosis accompanied by the cleavage of caspase-3 and PARP."
16923120
reach
"The JNK activity specific inhibitor, SP600125, and siRNA directed against JNK were used to block JNK and c-Jun pathway."
21943220
reach
"While these effects were reversed after JNK/c-Jun pathway was blocked by SP600125 (JNK pathway inhibitor), indicating the pathway was involved in NiONPs-induced excessive collagen formation."
36410144
eidos
"Moreover , siG6PD increased the reporter activity of MGAT3 promoters , while inhibition of c-Jun by SP600125 decreased the reporter activity ( Fig. 5g , Supplementary Fig. 6F ) ."
32719549
sparser
"As expected, the phosphorylation of p65 and c-jun was inhibited in M0 and M1 macrophages by Bay11-7082 and SP600125, respectively."
31964911