IndraLab

Statements

Input activates USP18. 3 / 3
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"In summary , our modeling results suggest that a prolonged input is required to initiate USP18 upregulation ."
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"Once the input duration is prolonged enough to induce USP18 upregulation , the negative regulation by USP18 overrides the positive regulation by ISGF3 , resulting in desensitization ."
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"Computational modeling suggests a delayed negative feedback loop through USP18 Based on our experimental results , we postulated that the opposite effects induced by short versus prolonged pretreatment inputs might be caused by different expression kinetics of ISGF3 components and USP18 : a short input is sufficient to trigger ISGF3 expression and thereby the priming effect , whereas a prolonged input is required to induce USP18 expression and hence desensitization ."
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