IndraLab

Statements

USP8 binds AIP4. 2 / 2
| 2
sparser
"A direct interaction between USP8 and AIP4 has not been reported, and it is possible that instead of directly deubiquitinating AIP4, USP8 may alter the ability of other E3 ligases (or perhaps of AIP4 itself) to stimulate AIP4 K63 polyubiquitination ( xref )."
20484045
sparser
"USP8 interacts with AIP4 and retains this E3 ubiquitin ligase in a state in which it can interact with FLIP S . Under these conditions FLIP S undergoes ubiquitin-mediated degradation, leaving the cell susceptible to TRAIL-induced apoptosis."
20484045