IndraLab

Statements

SCN1A activates autophagy. 3 / 3
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"Combined with the phosphorylated proteome results, we found that Pak5, Grin2b, Scn1a, BcaN, and L1cam may be involved in p53/mtor-mediated autophagy and apoptosis pathways."
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"Using phosphorylated proteomics and PRM validation, we found that Pak5, Grin2b, Scn1a, BcaN, L1cam and Braf are closely correlated with the targets of the web-based pharmacological screen and may be involved in p53/mTOR-mediated autophagy and apoptosis pathways."
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"Thus, the NAC1- mediated autophagy may be exploited as a new target for enhancing the efficacy of cisplatin against ovarian cancer and other types of malignancies."
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