IndraLab

Statements

Hypoxia activates BAP1. 5 / 5
| 5
reach
"In this study, we found that hypoxia-induced BAP1 enhances erastin-induced ferroptosis in NPC by stabilizing H2A.Studies have shown that many tumor cells under a hypoxic microenvironment are less sensitive to chemotherapeutic agents because these agents typically require oxygen for maximum activity [12]."
39245739
reach
"Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in nasopharyngeal carcinoma by stabilizing H2A."
39245739
reach
"Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in NPC by stabilizing H2A."
39245739
reach
"Ferroptosis inducers targeting BAP1 may be an effective way to reduce drug resistance in NPC, especially in the hypoxic microenvironment.In conclusion, our study initially validated that hypoxia-induced BAP1 enhanced erastin-induced ferroptosis in NPC by stabilizing H2A (Fig. 7)."
39245739
reach
"We found that hypoxia significantly increased the mRNA and protein expression levels of BAP1 in both HNE1 and 6-10B cells after exposed to hypoxia for 24 h, whereas other 5 ferroptosis-related genes showed no significant difference (Fig. 3A and B)."
39245739