IndraLab

Statements

PD-307243 activates KCNH2. 5 / 5
| 5
reach
"In the whole-cell recordings, the extracellular application of PD-307243 concentration-dependently increased the hERG current and markedly slowed hERG channel deactivation and inactivation."
18042732
reach
"At more positive voltages, PD-307243 induced an I (to)-like upstroke of hERG current."
18042732
reach
"Inside-out patch experiments revealed that PD-307243 increased hERG tail currents by 2.1 +/- 0.6 (n = 7) and 3.4 +/- 0.3-fold (n = 4) at 3 and 10 muM, respectively, by slowing the channel deactivation but had no effect on channel activation."
18042732
reach
"PD-307243 slowed the rate inactivation and increased hERG tail currents by 3.4-fold at 10 muM, but had no effect on rates of channel activation or deactivation [XREF_BIBR] [XREF_BIBR]."
24721650
reach
"In contrast, PD-307243, a structure analog of PD-118057, increased hERG current with the rates of both inactivation and deactivation being slowed markedly [16] ."
19426677