IndraLab

Statements

PD-307243 activates KCNH2. 4 / 4
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"Inside-out patch experiments revealed that PD-307243 increased hERG tail currents by 2.1 +/- 0.6 (n = 7) and 3.4 +/- 0.3-fold (n = 4) at 3 and 10 muM, respectively, by slowing the channel deactivation but had no effect on channel activation."
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"At more positive voltages, PD-307243 induced an I (to)-like upstroke of hERG current."
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"In the whole-cell recordings, the extracellular application of PD-307243 concentration-dependently increased the hERG current and markedly slowed hERG channel deactivation and inactivation."
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"PD-307243 slowed the rate inactivation and increased hERG tail currents by 3.4-fold at 10 muM, but had no effect on rates of channel activation or deactivation [XREF_BIBR] [XREF_BIBR]."
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