IndraLab

Statements

Dioxygen inhibits CASP1. 3 / 3
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"Moreover, UgU elicited mitochondrial superoxide generation in a dose dependent manner, and a specific scavenger of mitochondrial reactive oxygen species (ROS) diminished UgU induced IL-1beta and caspase-1 activation."
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"Rather, they induced a cellular state inhibitory to both the autoproteolytic and substrate cleavage activities of caspase-1 which was reversed by the reactive oxygen species (ROS) scavenger N-acetyl-cysteine but not by reducing agents or nitric oxide pathway inhibitors."
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"These results suggest that Phox generated reactive oxygen species downregulate caspase-1, thereby keeping the inflammasome in check and limiting ANCA induced inflammation."
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