IndraLab

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USP8 increases the amount of PI3K. 2 / 2
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"Although the decreased PI3K and P-Akt levels were found by silenced EGFR, the overexpressed USP8 was shown to increase PI3K/P-Akt expression over EGFR silencing and thereby increase the NF-kB signal activation ( Figure 7 )."
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"Thereby, together with these data, it can be concluded that the elevated level of USP8 not only increases the expression of EGFR, PI3K, and P-Akt but also might increase the PI3K and P-Akt expression over EGFR silencing where the PI3K and P-Akt well established the downstream target of EGFR ( Figures 6C, D )."
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