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S1 inhibits HCN4. 1 / 1

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"Replacement of leucine 272 in S1 of HCN4 by the corresponding phenylalanine present in HCN2 decreased tau act of HCN4 to 149 ms. Conversely, activation of the fast channel HCN2 was decreased 3-fold upon the corresponding mutation of F221L in the S1 segment."

12813043

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IndraLab

Statements

S1 inhibits HCN4. 1 / 1

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