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Mesalamine inhibits RELA. 7 / 7
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"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."
29085602
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"We further investigated whether siPAK1 or 5-ASA reduced p65 at the transcriptional level."
26036343
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"Here we demonstrate that 5-ASA induced degradation of p65 protein (XREF_FIG C) indicative of PPARgamma 's E3 ubiquitin ligase activity."
26036343
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"Nevertheless, NF-kappaB p65 and NF-kappaB p65 mRNA expression was significantly reduced in DSS induced UC rats treated with QCWZD and mesalazine (P < 0.05, resp., Figures XREF_FIG and XREF_FIG)."
27413386
sparser
"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."
29085602
reach
"Moreover, mesalamine can also inhibit phospohorylation of the p65 subunit of NF-kappaB, a post-translational modification that is essential for its transcriptional activity."
19707368
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"For example, Sulfasalazine acts on the nuclear translocation of NF-κB. Mesalamine inhibits post-transcriptional changes in p65 (102)."
34434197