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P14_3_3 binds BAP1. 8 / 8
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"Next, we tested the hypothesis that the BAP1 interaction with 14-3-3 releases the binding between 14-3-3 and Bax, which further facilitates cell death."
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"Another study in 2018, showed that BAP1 interacts with the protein 14-3-3 in neuroblastoma cells causing the release of Bax and the decrease of pro-survival factors such as Bcl-2, to promote apoptosis via the intrinsic pathway.[ xref ]"
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"These results suggest that BAP1 interaction with 14-3-3 prevents cell survival signaling, which is essential for growth of the neuroblastoma cells (Fig.  xref )."
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"BAP1 binding to 14-3-3 facilitate the apoptotic signaling in neuroblastoma."
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"The interaction between BAP1 and 14-3-3 protein was confirmed by performing the co-IP of FLAG-tagged BAP1 and pull-down of endogenous 14-3-3 in neuroblastoma cells (Fig.  xref )."
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"The reciprocal IP using 14-3-3 antibodies also indicated the formation of the complex between BAP1 and 14-3-3 (Fig.  xref )."
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"In addition, fluorescence resonance energy transfer (FRET) assay demonstrated a direct interaction between BAP1 and 14-3-3 (Fig.  xref )."
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"We could also confirm that the short fragment of BAP1-ULD domain and 14-3-3-alpha helices 7-9 regions facilitate interaction between these two proteins (Fig.  xref ), while the interaction between BAP1 and 14-3-3-σ inactive mutants were reduced compared to the full-length 14-3-3-σ (Fig.  xref )."
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