IndraLab

Statements

USP7 inhibits methylation. 3 / 3
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eidos
"Mechanistic study demonstrated that USP7 suppresses DNMT1 recruitment and DNA methylation through its deubiquitinase activity and the interaction with DNMT1 ."
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eidos
"Thus , USP7 not only plays a role in stabilizing DNMT1 and UHRF1 , but also serves to suppress excessive DNA methylation by DNMT1 ."
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"Both physical interaction with DNMT1 and deubiquitinase activity are required for USP7 to inhibit DNMT1 replication fork association and DNA methylation in USP7-KO cells ."
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