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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP7 inhibits methylation. 3 / 3

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"Mechanistic study demonstrated that USP7 suppresses DNMT1 recruitment and DNA methylation through its deubiquitinase activity and the interaction with DNMT1 ."

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"Thus , USP7 not only plays a role in stabilizing DNMT1 and UHRF1 , but also serves to suppress excessive DNA methylation by DNMT1 ."

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"Both physical interaction with DNMT1 and deubiquitinase activity are required for USP7 to inhibit DNMT1 replication fork association and DNA methylation in USP7-KO cells ."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP7 inhibits methylation. 3 / 3

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