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USP1 increases the amount of phosphorylated AKT. 2 / 2
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"Finally, we found that inhibition of USP1 downregulated the expression of ID1 and p-AKT, and upregulated ID1 expression could reverse the suppressive effects of USP1 inhibitor in B-ALL cells."
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"A previous report showed that downregulation of USP1 increased p-Akt levels in muscle of fasting mice with little effect on p-Akt levels [24], while another report showed that downregulation of USP1 significantly increased p-Akt levels and slightly increased p-Akt levels in lung cancer cells [51]."
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