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USP15 inhibits NFkappaB. 4 / 4
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"In addition, USP15 dose-dependently inhibited RIG-I-N-triggered IFN-beta-Luc, ISRE-Luc, NF-kappaB-Luc, and IRF3-Luc reporter activities."
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"Thus , USP15 inhibits NF-kB signaling and its downstream target genes by deubiquitination and stabilization of IkB in mammalian cells [ 33 ] , as illustrated in Figure 2 ( left ) ."
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"NF-kappaB signaling is negatively regulated by USP11 or USP15 mediated removal of K48 linked ubiquitin chains from IkappaBalpha [XREF_BIBR, XREF_BIBR]."
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"As shown in XREF_FIG e and XREF_FIG f, knockdown of USP15 increased the activation of NF-kappaB (5.9 vs 12.9, p = 1.92E-04) and IRF3 (15.6 vs 26.5, p = 1.04E-03) through reporter assays."
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