IndraLab

Statements

USP15 inhibits TET2. 4 / 4
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"USP15 inactivates TET2 and inhibits TET2 binding to substrate DNA."
| PMC
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"Deletion of Usp15 in melanoma stimulates chemokine expression and TILs in a TET2 dependent manner, leading to increased response to immunotherapy and extended life span of tumor bearing mice."
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"USP15 catalyzes the removal of K1299 linked monoubiquitin and negatively regulates TET2 activity."
32948596
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"USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2."
32948596