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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP15 inhibits TET2. 4 / 4

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"USP15 inactivates TET2 and inhibits TET2 binding to substrate DNA."

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"Deletion of Usp15 in melanoma stimulates chemokine expression and TILs in a TET2 dependent manner, leading to increased response to immunotherapy and extended life span of tumor bearing mice."

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"USP15 catalyzes the removal of K1299 linked monoubiquitin and negatively regulates TET2 activity."

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"USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP15 inhibits TET2. 4 / 4

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