IndraLab

Statements

USP14 inhibits FASN. 4 / 4
| 4
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"USP14 also increases liver lipid synthesis by inhibiting FASN degradation and promotes nonalcoholic fatty liver disease progression [ 19 ]."
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"Furthermore, CHX analysis confirmed that USP14 silencing significantly promoted the degradation of endogenous FASN (Fig. 4h and Supplementary Fig. 5G), suggesting that USP14 can lengthen the half-life of FASN protein."
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"As a result, USP14 overexpression reduced enzymatic activity of FASN, whereas USP14 deficiency significantly increased FASN activity in cancer cells (Figure 3a,b)."
| PMC
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"This result further confirms that USP14 negatively regulates the protein level and the activity of FASN in cancer cells."
| PMC