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"However, in this study the authors showed that USP48 inhibits only JNK signaling upon TNFR1 stimulation in epithelial cells but does not affect NF-κB, MAPK and cell death signaling [54] indicating mutually nonexclusive cell type- and DUB-specific functions of USP48 and OTUD7b with respect to the regulation of TRAF2.The formation of the apoptosis-inducing complex-IIa (RIPK1-independent) and complex-IIb (RIPK1-dependent) is induced by insufficient pro-survival signals from complex-I [55]."