IndraLab

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JAK2 inhibits KCNQ4. 4 / 4
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"KCNQ4 is closely related to the non-receptor tyrosine protein kinase JAK 2, which reduces the activity of KCNQ4 in Xenopus oocytes [20], while PI3K/AKT is up-regulated by JAK2 [21]."
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"In conclusion, JAK2 downregulates KCNQ4 activity and thus counteracts K (+) exit, an effect which may contribute to cell volume regulation."
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"Downregulation of KCNQ4 by Janus kinase 2."
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"These results indicated that BC069792 inhibited the expression of JAK2 protein and the phosphorylation of AKT protein by up-regulating KCNQ4, decreased the expression of p-AKT, and then inhibited the progression of breast cancer.To further verify whether BC069792 exerts biological functions through competitive adsorption of hsa-miR-658 and hsa-miR-4739, we performed rescue experiments."
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